Effectiveness of clozapine: a study from North India

Dutta A, Grover S, Chakrabarti S, Kulhara P, Avasthi A, Basu D, Das P et al. · PGIMER, Chandigarh

Asian Journal of Psychiatry, 2010;3(1):16–19 · doi:10.1016/j.ajp.2009.12.002

ABSTRACT

Evaluated real-world effectiveness of clozapine in treatment-resistant schizophrenia (TRS) in a North Indian tertiary hospital cohort. At the time of publication, few Indian studies had systematically evaluated clozapine in TRS, with most data derived from Western populations or limited to case reports.

TRS schizophrenia · Clozapine · North India

KEY FINDINGS

• Clozapine demonstrated significant effectiveness in treatment-resistant schizophrenia in the Indian context

• Improvements in positive symptoms; some benefit in negative symptoms; reduction in extrapyramidal side effects including tardive dyskinesia

• One of few effectiveness studies from the Indian subcontinent — widely cited in subsequent Indian clozapine literature